三年前，「地球男」的冧女秘技不敵「火星男」的一遍真心，程子欣情歸方啟宏，敗北的張申然再戰情場，想與「女股神」楊鴦鴦速戰速決，卻煞出勁敵「法國男」程子建！上集蛙兄戰死沙場，古天樂和吳彥祖兩位單身男神勢均力敵，今集小小八爪魚上場，高圓圓有一顆恨嫁的心，卻愛得很難；楊千嬅烈女不怕死， 卻患上Ａ餐Ｂ餐選擇恐懼症，周渝民的法式浪漫又能否打動單身女股神？前度再次出現，使古天樂方寸大亂！杜琪峰和韋家輝再在摩天大廈隔樓玩緣份遊戲，以超喜感打破續集魔咒，《單身男女2》兩女神配三男神，火星再撞地球！
Madcap romance is multiplied in Johnnie To and Wai Ka-Fai’s sequel to their hit romantic comedy Don’t Go Breaking My Heart. Years after Zixin (Gao Yuanyuan) chose Qihong (Daniel Wu) over Shen-Ran (Louis Koo), Zixin finds herself working for the “Goddess of Stocks” Yang Yang-Yang (Miriam Yeung), Shen-Ran’s current flame. Zixin and Qihong are engaged but having difficulties, giving Shen-Ran an opportunity to reengage with Zixin – at the cost of his relationship with Yang-Yang, naturally. Meanwhile, Yang- Yang meets her own alternative suitor: Paul (Vic Chou), who coincidentally is Zixin’s brother! Readily acknowledging the formulaic nature of the genre, Johnnie To and Wai Ka-Fai entertainingly deconstruct the romantic comedy with surprising creativity and sly, self-referential wit.
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